How does Cialis work

How Does viagra cialis online pharmacy pharmacy Work

An erection occurs when blood is pumped to the penis which makes it hard allowing sexual intercourse. This action is impossible in some men because they experience penile dysfunction. More and more men in recent years have been admitting that this is a problem for them and asking for help. In Bothell Washington, a small company began research and subsequent development of a drug called Cialis to help men with their problem.

There are a group of drugs called PDE5 enzyme inhibitors and Cialis fits in to this. It was discovered by researchers that cyclic guanosine monophosphate (cGMP) was the key to achieving and sustaining an erection. Following sexual stimulation a chain reaction occurs in the tissue of the penis of a man that results in elevated levels of cGMP. With sufficient levels of cGMP, the penis can remain erect and the more cGMP the more robust is the erection.
Cialis works by blocking the enzyme PDE5 which is responsible for neutralization of cGMP. Because Cialis is very highly selective inhibitor of PDE5 it is very effective. Cialis on its own does not cause an erection, Cialis blocks the degradation of cGMP produced in reaction to sexual stimulation. It is important to understand that if you are not being sexually stimulated there is no cGMP to protect so Cialis remains in the background. This is why Cialis is so different from some other medications for the problem. There were many drugs for penile dysfunction before Cialis, which induced a chemical reaction instead of one which reacted to stimulation. It was found that this was one of the main complaints by couples who were taking other types of drugs and did not seem to be natural.

By blocking the enzyme PDE5 Cialis effectively causes the blood vessels in the penis to relax and allowing the blood to flow and enlarge this. By compressing the veins at the base of the penis the flow of blood from this is restricted and the erection is maintained. Following intercourse these veins relax allowing the blood to flow out as normal. Correctly used Cialis, means that sexual activity is as natural as not having to use it at all.Because Cialis is easily absorbed into the bloodstream it can be taken from 30 minutes up to 12 hours prior to sexual activity and Cialis is active for between 24 and 36 hours. According to the manufactures, because of its unique onset and duration periods, Cialis can be taken many hours before sexual activity is contemplated.

Boceprevir, Merck’s Investigational Oral Hepatitis C Protease Inhibitor, Receives FDA Priority Review and EMA Accelerated Assessment

January 06, 2011 08:00 AM Eastern Time



WHITEHOUSE STATION, N.J.--(BUSINESS WIRE)--Merck, known as MSD outside the United States and Canada, announced today that regulatory applications for boceprevir, Merck's investigational oral hepatitis C virus (HCV) protease online pharmacy viagra, were submitted in 2010 and have been accepted for expedited review in both the U.S. and the European Union.



The U.S. Food and Drug Administration (FDA) granted the New Drug Application (NDA) for boceprevir Priority Review status, a designation given to drugs that offer major advances in treatment, or provide a treatment where no adequate therapy exists. FDA's goal for completing a Priority Review is six months.



Additionally, the European Medicines Agency (EMA) accepted the Marketing Authorization Application (MAA) for boceprevir for accelerated assessment. Accelerated assessment is available for products that respond to unmet medical needs or represent a significant improvement over current treatment options within a major public health interest such as treatment of hepatitis C virus infection.



Data in the NDA and MAA have been provided in support of the proposed use of boceprevir for the treatment of chronic HCV genotype 1 infection, in combination with standard therapy, in adult patients with compensated liver disease who are previously untreated or who have failed previous therapy.



"We are pleased that the FDA and EMA have accepted boceprevir for expedited review. Our goal is to be able to bring forward a new treatment option for patients living with chronic hepatitis C, and we are now closer to that goal,” said Dr. Peter S. Kim, Ph.D., president, Merck Research Laboratories.



Merck's global commitment to advancing hepatitis therapy



Merck is committed to building on its strong legacy in the field of viral hepatitis by continuing to discover, develop and deliver vaccines and medicines to help prevent and treat viral hepatitis. Extensive research efforts are underway to develop differentiated oral therapies that bring innovation to viral hepatitis care.



About Merck



Today's Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, and consumer care and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to healthcare through far-reaching policies, programs and partnerships. For more information, visit http://www.merck.com/.



Forward-Looking Statement



This news release includes “forward-looking statements” within the meaning of the safe harbor provisions of the United States Private Securities Litigation Reform Act of 1995. Such statements may include, but are not limited to, statements about the benefits of the merger between Merck and Schering-Plough, including future financial and operating results, the combined company’s plans, objectives, expectations and intentions and other statements that are not historical facts. Such statements are based upon the current beliefs and expectations of Merck’s management and are subject to significant risks and uncertainties. Actual results may differ from those set forth in the forward-looking statements.



The following factors, among others, could cause actual results to differ from those set forth in the forward-looking statements: the possibility that the expected synergies from the merger of Merck and Schering-Plough will not be realized, or will not be realized within the expected time period; the impact of pharmaceutical industry regulation and health care legislation; the risk that the businesses will not be integrated successfully; disruption from the merger making it more difficult to maintain business and operational relationships; Merck’s ability to accurately predict future market conditions; dependence on the effectiveness of Merck’s patents and other protections for innovative products; the risk of new and changing regulation and health policies in the U.S. and internationally and the exposure to litigation and/or regulatory actions.



Merck undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in Merck’s 2009 Annual Report on Form 10-K and the company’s other filings with the Securities and Exchange Commission (SEC) available at the SEC’s Internet site (http://www.sec.gov/).



Contacts

Merck

Media:

Ian McConnell, 908-423-3046

Robert Consalvo, 908-295-0928

or

Investors:

Joe Romanelli, 908-423-5088



Source

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Apple profits nearly double as iPhone sales soar

See also: cialis | 

 

Source BBC news

iPhone sales more than doubled

Latest profits for computer giant Apple have beaten forecasts, helped by higher-than-expected iPhone sales.

Apple reported quarterly net profits of $5.99bn (£3.6bn), nearly double what it made a year ago. Revenue was $24.67bn, a rise of 83%.

The figures are the latest in a string of good results from US technology companies.

Apple sold 18.65 million iPhones, a rise of 113%. But iPad sales were 4.69 million, below analysts' expectations.

Challenges ahead

Apple chief executive Steve Jobs said in a statement: "We're firing on all cylinders."

Mr Jobs, who went on medical leave in January with an undisclosed illness, continued: "We will continue to innovate on all fronts throughout the remainder of the year."

But the iOS - Apple's operating system for the iPhone and iPad - faces huge challenges from the likes of Google.

A report last month from market research firm Nielsen found Google's Android had become the most popular operating system among US smartphone users - accounting for 29% of the market, in comparison to iOS at 27%.

Google has released Honeycomb, the latest version of Android designed for cheap cialis, and Canadian firm RIM, maker of the BlackBerry, recently launched their first tablet.

'Dynamite numbers'

Sales of the company's computers were strongly higher, up by 28% from a year ago driven by its improved MacBook Pro.

Apple's figures were not uniformly positive. Besides the iPad, another disappointment was sales of its one-time star, the iPod, down by 17% on the year at 9 million units.

Most analysts were enthusiastic about the figures.

Channing Smith, portfolio manager at Capital Advisors growth fund, said: "Dynamite numbers across the board. The only hiccup is lower than expected iPad numbers."

The day-to-day running of Apple is currently being done by chief operating officer Tim Cook.

Posted in: world news

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